Opthalmology & Eye Care

Eye: Developmental Biology

Eye development is initiated by the master control gene Pax-6, a home box gene with known homologues in humans, mice (small eye), and Drosophila (eyeless The Pax-6 sequence locus could be a transcription issue for the assorted genes and growth factors concerned in eye formation. Eye morphogenesis begins with the examination, or outgrowth, of the optic grooves or sulci. During the invagination of the optic cup, the ectoderm begins to thicken and form the lens placed, which eventually separates from the ectoderm to form the lens vesicle at the open end of the optic cup. Further differentiation and mechanical rearrangement of cells in and around the optic cup gives rise to the totally developed eye.